Surprise Sunday Bad News And My Weekly Look At Viruses In Wastewater
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#COVID19
85 posts60 participants3 posts today
US research
Dysautonomia in long COVID is prevalent and could explain the frequency of symptoms
https://www.medrxiv.org/content/10.1101/2025.03.24.25324564v1
#dysautonomia @dysautonomia #pots @pots @longcovid
#LongCovid #PwLC #PostCovidSyndrome #LC #PASC #postcovid
#CovidBrain
@covid19 #COVIDー19 #COVID19 #COVID #COVID_19 #SARSCoV2
medRxiv · Dysautonomia in long COVID is prevalent and could explain the frequency of symptomsBackground Long COVID presents with a variety of symptoms. Some of those symptoms could be related to autonomic dysfunction. Our aim is to evaluate the prevalence of autonomic dysfunction in long COVID patients.
Methods We conducted a cross-sectional study and included all consecutive patients enrolled in several clinical research studies. We performed the following autonomic dysfunction markers: heart rate variability, heart rate, systolic and diastolic blood pressure changes during NASA lean test, cardiopulmonary exercise testing and a COMPASS-31 scale. We used linear regression to calculate the contribution of each dysautonomia measure on symptom burden as measured by the modified COVID-19 Yorkshire scale.
Results We included 100 patients for this study. Our sample had a mean age of 56+/-11 years, included 53% minorities and 32% were women. Dysautonomia as defined by an abnormal COMPASS-31 was seen in 82%; 95% 72-89 while cardiovascular resting dysautonomia as represented by an abnormal heart rate variability was seen in 60%; 95% 48-70 of the population, orthostatic hypotension in 12% and POTS in 10%. In our adjusted analysis, we found that the beta coefficient for the COMPASS-31 score (0.37) was significant on changes in a self-reported long COVID symptom burden. The orthostatic intolerance and gastrointestinal domains of the COMPASS-31 was associated the highest long COVID symptom burden.
Conclusion Dysautonomia is common in long COVID patients and contributes to the overall symptoms seen in long COVID. Identifying dysautonomia has important diagnostic and therapeutic implications.
### Competing Interest Statement
The authors have declared no competing interest.
### Clinical Trial
NA
### Funding Statement
Yes
### Author Declarations
I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.
Yes
The details of the IRB/oversight body that provided approval or exemption for the research described are given below:
All studies were approved by the research ethics committees at the Miami VAHS and NOVA Southeastern University and all participants signed informed consent prior to participation. Miami VA is the IRB of record
I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals.
Yes
I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).
Yes
I have followed all appropriate research reporting guidelines, such as any relevant EQUATOR Network research reporting checklist(s) and other pertinent material, if applicable.
Yes
Data cannot be shared publicly because it is owned but the Veterans Affairs.
New UK research:
Long-term effects of #SARSCoV2 infection on blood vessels and blood pressure
"Persistent vascular dysfunction and BP increase post-COVID-19 underscore the need for further studies on the long-term risk of hypertension & cardiovascular disease”
@longcovid
#LongCovid #PwLC #LC #PASC #postcovid
@covid19 #COVIDー19 #COVID19 #COVID #COVID_19 #SARSCoV2 @novid@chirp.social #novid @novid@a.gup.pe #CovidIsNotOver
Huh. New #CovidIsAirborne case-controlled study from Ontario in Feb 2021.
#COVID19 outbreak at a residential apartment building in Northern Ontario, Canada
> being on the upper floors (OR: 10.4; 95% CI: 1.63–66.9) and within three adjacent vertical lines (OR: 28.3; 3.57–225) were both significantly associated with being a case of COVID-19, after adjusting for age. An assessment of the building’s ventilation found uncontrolled air leakage between apartment units. Findings from the multiple components of this investigation are suggestive of aerosol transmission between units.
https://doi.org/10.1017/S0950268824000256
H/t @DickZoutman
#Followerpower Im Rahmen einer Gesprächsrunde zur Aufarbeitung der #CoronaKrise wurde die folgende These formuliert. Wenn ihr in der Lage seid, diese sachlich fundiert zu veri- oder falsifizieren, bitte um Kommentar oder (wenn längerer Text) gerne auch einen Link mit kurzem Kommentar, warum ihr diesen Link für geeignet haltet. Falls du dich in einem fachlich kompetenten Umfeld bewegst, bin ich dich für's Weiterleiten /#boost auch sehr dankbar 
> These: Die im Verlauf der Pandemie aufgetretenen Krisen im Gesundheitssystem, insbesondere der Personalmangel in den Krankenhäusern, wurden auch dadurch verursacht, dass Mitarbeiter nur aufgrund eines positiven PCR-Tests nicht weiter an der Behandlung und Pflege von Krankenhauspatienten mitwirken konnten. Richtig wäre gewesen, sie erst beim Auftreten von Symptomen vom direkten Kontakt mit Patienten abzuziehen. (Ende der These)
It's time to start digging in to my mask project!
I need good, solid resources to back up a presentation I'll be giving to the local public. What are the most reliable and ethical doctors, journalists, advocates, research, statistics, or sites that you've seen?
I'll be talking about air quality, advocating environmental justice through citizen science and mutual aid, and my focus is going to be ventilation and masking.
The program is organized by a local group of folks that started putting up air sensors all over town because of toxic chemical leaks from nearby refineries. They got a grant through a university, and they may be able to help me out in getting an air quality sensor so I can test the CO2 in local buildings. I'd also like to be able to pass out some mask samples. I've been trying to find info on other things like sip valves, elastomeric respirator exhaust valve filter adapters, good sites to buy masks and so on.
Since these issues got politicized and the CDC and WHO are increasingly corrupt/hamstrung, finding good info is a fuckin MESS. I could really use some help!
What's been very interesting to me is, the folks who promote masking are usually ALSO right on other issues. Masks are required at the local anarchist book fairs, for example, which to me says a LOT. The people I follow here on Mastodon who are solidly against genocide, fascism, capitalism, and lesser evilism are the SAME people who are solidly for issues like universal healthcare, right to repair, accessibility, direct action, labor organizing, etc etc-- you have a moral consistency that inspires my respect and hope, and I want to learn more from you!
Next post below will be where I list the sources I've collected, updating as I go.
#masks
#respirators
#ventilation
#COVID19
#covidCautious
#birdFlu
#H5N1
#measles
#publicHealth
#airQuality
#environmentalJustice
#mutualAid
#purpleAir
#citizenScience
Continued thread
Fun facts about my spreadsheet of #COVID19 studies: If you simply read down the column of brief quotes captured from each study:
- It'd take you eight hours to get through the summaries, and
- You'll never take another COVID infection as lightly as you do today.
My spreadsheet of #COVID19 studies finding longer-term risks from infections has grown to 1,900 studies. Recent studies find:
- Increasing Long COVID risks with reinfection in kids
- Higher rates of bacterial, fungal, and viral infections for 12 months after COVID
- Vascular function may not improve within 1.5 years after COVID-19
- Brain alterations in children following mild COVID-19
- COVID-19 is associated with poor sperm quality
https://docs.google.com/spreadsheets/d/12VbMkvqUF9eSggJsdsFEjKs5x0ABxQJi5tvfzJIDd3U/edit?usp=sharing
Google DocsCOVID-19/SARS-CoV-2 Studies
STUDY finds that Long #COVID19 patients at a rehabilitation clinic showed a lower quality of life than patients with asthma or COPD, accompanied by poor mental health. Association of SSD (somatic symptom disorder) with DLI (daily life impairment) was stronger in PCS than in asthma, and was not significant in COPD.
NatureThe implications of somatic symptom disorder on the impairment of daily life are greater in post-COVID syndrome than in asthma or COPD - results of a cross-sectional study in a rehabilitation clinic - Scientific ReportsThe aim was to compare the relationship between somatic symptom disorder (SSD), anxiety, depression, clinical symptoms, and daily life impairment (DLI) in post-COVID syndrome (PCS), asthma and chronic obstructive pulmonary disease (COPD). In a cross-sectional study, 371 patients (161 PCS, 121 asthma, 89 COPD) of a pulmonary rehabilitation clinic received the questionnaires PHQ-15 (Patient Health Questionnaire-15) and SSD-12 (Somatic Symptom Disorder-12) to determine SSD, GAD-7 (Generalized Anxiety Disorder-7) to determine anxiety disorder, and PHQ-9 (Patient Health Questionnaire-9) to determine depression. Lung function was estimated using whole-body plethysmography. Predictors for DLI were assessed by regression models and ROC analyses. Association of SSD with DLI was stronger in PCS (odds ratio 13.8; 95% confidence interval 1.7-109.9) than in asthma (8.5; 2.4–30.1), and was not significant in COPD (1.9; 0.5–7.5). In asthma and COPD, strongest predictors were GAD-7 (15.0; 1.9-116.8) and PHQ-9 (8.9; 1.1–71.8), respectively. Diffusion capacity was predictive in COPD (0.947; 0.916–0.979) and asthma (0.967; 0.943–0.993), but not in PCS. To conclude, SSD appears to have greater impact on DLI in PCS than asthma or COPD patients. This should be recognized appropriately during rehabilitation. Furthermore, increased psychological comorbidity should also be considered and adequately treated in asthma and COPD if necessary.
STUDY finds evidence of potential brain alterations in children following mild #COVID19. "Our results showed increased cortical area, volume, and LGI (Local Gyrification Index) in the left superior parietal cortex, as well as increased cortical thickness in the left lateral occipital cortex among children with COVID-19. SCN analysis revealed altered network topology and larger CP (choroid plexus) volumes in the COVID group, suggesting virus-induced neuroinflammation."
NatureMultimodal MRI analysis of COVID-19 effects on pediatric brain - Scientific ReportsThe COVID-19 pandemic has raised significant concerns regarding its impact on the central nervous system, including the brain. While the effects on adult populations are well documented, less is known about its implications for pediatric populations. This study investigates alterations in cortical metrics and structural covariance networks (SCNs) based on the Local Gyrification Index (LGI) in children with mild COVID-19, alongside changes in non-invasive MRI proxies related to glymphatic function. We enrolled 19 children with COVID-19 and 22 age-comparable healthy controls. High-resolution T1-weighted and diffusion-weighted MRI images were acquired. Cortical metrics, including thickness, surface area, volume, and LGI, were compared using vertex-wise general linear models. SCNs were analyzed for differences in global and nodal metrics, and MRI proxies, including diffusion tensor imaging along the perivascular space and choroid plexus (CP) volume, were also assessed. Our results showed increased cortical area, volume, and LGI in the left superior parietal cortex, as well as increased cortical thickness in the left lateral occipital cortex among children with COVID-19. SCN analysis revealed altered network topology and larger CP volumes in the COVID group, suggesting virus-induced neuroinflammation. These findings provide evidence of potential brain alterations in children following mild COVID-19, emphasizing the need for further investigation into long-term neurodevelopmental outcomes.
STUDY: Those with pre-existing neurological conditions who were hospitalized with #COVID19 were 90% more likely to die in the following 3.5 years. Whether hospitalized or not, they were significantly more likely to experience a MACE (Major adverse cardiac event) compared to non-COVID-19 patients.
https://www.sciencedirect.com/science/article/abs/pii/S0022510X25000942
www.sciencedirect.comLong-term outcomes of patients with a pre-existing neurological condition after SARS-CoV-2 infectionThis study investigated post COVID-19 outcomes of patients with pre-existing neurological conditions up to 3.5 years post-infection.This retrospective…
STUDY of children with Long #COVID19 referred to a specialist found that, after six months, 55% reported improvement in their daily functioning, 41% reported no change, and 4% reported functional deterioration.
Good news more than half found improvement. Bad news almost half had no change or worsening symptoms.
https://www.sciencedirect.com/science/article/pii/S1054139X25000667
www.sciencedirect.comCharacterisation and Management of Children and Young People Referred to a Paediatric Tertiary Post-COVID ServicePost-COVID condition (PCC) emerged following the 2020 coronavirus pandemic and required rapid service development to manage affected patients. This ev…
Here's an animated map showing the spread of the XFJ variant. The first sample was detected in Cote d'Ivoire in late August. After a long pause, a second sample was detected in South Africa in December. Then it appeared in New York in late February and soon began spreading more widely.
Recently classified XFJ is a recombinant of LF.7 and LS.2. LF.7 is descended from FLiRT JN.1.16.1. LF.7 added several Spike mutations: T22N, S31P, K182R, R190S and K444. LS.2 was descended from JN.1.18.5.
Audio credit:
Swarm_Bees_outdoor_stereo by leonseptavaux -- https://freesound.org/s/573839/ -- License: Attribution 4.0
With the LP.8.1.* variant on the way to dominance in most places, it is time to ponder which variant might drive the next wave.
The leading contenders at this point are LF.7.7.2, LF.7.9, NB.1.8.1, XEC.25.1 XFH and (new) XFJ.
I show them here using a log scale, so you can compare their growth rates vs the most common LP.8.1.* sub-lineage: LP.8.1.1. There are more recent samples available, but the frequency analysis becomes increasingly distorted due to low volumes and patchy coverage.
An international emergency task force is urgently needed for Severe Long COVID and ME crisis cases https://thesicktimes.org/2025/04/04/an-international-emergency-task-force-is-urgently-needed-for-severe-long-covid-and-me-crisis-cases/ #ME #MECFS #LongCovid #Covid #Covid19 #CovidIsNotOver
The Sick Times - Chronicling the Long Covid crisis · An international emergency task force is urgently needed for Severe Long COVID and ME crisis cases - The Sick TimesWithout one, Severe advocates are putting themselves at risk. It’s time for advocacy organizations to step up. Writer’s note: In this essay, I deliberately capitalize different categories of ME in order to give each the weight and dignity they deserve. I also choose to distinguish between the Sick and the Well to highlight our status
"COVID-19 re-infection doubles risk of long COVID in kids, young adults, data reveal"
"These findings emphasize the ongoing risk of PASC with reinfection, regardless of severity."
www.cidrap.umn.eduCOVID-19 re-infection doubles risk of long COVID in kids, young adults, data revealThe second infection was also tied to a 50% or greater increase in several specific long-COVID conditions, including myocarditis and fatigue.
Illness Is Starting To Hit Sports Hard Again, Could It Be Long Covid?
2025-April-04 Friday
737 Americans Died Last Week From COVID 19
1,225,657 Americans Dead From COVID 19 In Total