Recent searches

No recent searches

Search options

Only available when logged in.
digitalcourage.social is one of the many independent Mastodon servers you can use to participate in the fediverse.
Diese Instanz wird betrieben von Digitalcourage e.V. für die Allgemeinheit. Damit wir das nachhaltig tun können, erheben wir einen jährlichen Vorausbeitrag von 1€/Monat per SEPA-Lastschrifteinzug.

Administered by:

Server stats:

814
active users

digitalcourage.social: AboutStatusProfiles directoryPrivacy policy

Mastodon: AboutGet the appKeyboard shortcutsView source codev4.4.1

#embryo

1 post1 participant0 posts today
flypapers

📰 "Quantifying neuronal differentiation using temporal topological persistence"
biorxiv.org/content/10.1101/20
#Drosophila #Sensory
#Embryo #Larva

bioRxiv · Quantifying neuronal differentiation using temporal topological persistenceNeuronal anatomical differentiation relies on coordinated neurite dynamics to establish class-type morphology during development. Recent advances in high-throughput time-lapse imaging techniques have transformed our ability to track such growth dynamics, yielding comprehensive anatomical datasets of neuronal morphologies at unprecedented rates. However, analyzing these complex datasets using traditional morphometrics requires manual feature selection, which leads to costly and biased quantification. To overcome these limitations, we applied the Topological Morphology Descriptor (TMD) to extract topological representations of neurons from time-lapse imaging of two cell types within the well-established Drosophila larval sensory dendritic arborization (da) system. We first used TMD to accurately classify the developmental trajectory of Class I da sensory neurons across embryonic and larval stages. However, TMD alone failed to distinguish class-type-specific morphology in Class III neurons, particularly in detecting altered branching rate dynamics in genetically modified mutants. To address this, we extended TMD to a Temporal Topological Morphology Descriptor (TTMD) to incorporate temporal dynamics. TTMD successfully classified mutations in Drosophila Class III da neurons, capturing altered branching rate dynamics in mutant phenotypes. These findings highlight the power of TTMD as an unbiased, scalable framework for analyzing neuronal growth dynamics and linking structural development to genetic and functional variation. ### Competing Interest Statement The authors have declared no competing interest.
WordofTheHour

#embryo : the germ of the plant, which is inclosed in the seed and which is developed by germination

- French: embryon

- German: der Embryo

- Italian: embrione

- Portuguese: embrião

- Spanish: embrión

------------

Thank you so much for being a member of our community!

Benjamin Carr, Ph.D. 👨🏻‍💻🧬

#Embryo editing debate is back:

Heritable polygenic editing: next frontier in #genomic #medicine?

In it Visscher suggest editing 10 bits of #DNA could reduce the prevalence of #Alzheimer’s or #schizophrenia by nearly 10-fold. Another 10 edits could diminish coronary artery #disease more than 30-fold, and 10 more edits could cut type 2 #diabetes by roughly 60-fold.
But doing so would be controversial, both at a scientific and moral level.
nature.com/articles/s41586-024 #genes #genetic #geneticediting

NatureHeritable polygenic editing: the next frontier in genomic medicine? - NatureWe discuss the potential consequences and ethical concerns of polygenic genome editing of human embryos to alter specific variants associated with polygenic diseases, highlighting the possibility of reducing disease susceptibility while exacerbating health inequalities.
WordofTheHour

#embryo : the germ of the plant, which is inclosed in the seed and which is developed by germination

- French: embryon

- German: der Embryo

- Italian: embrione

- Portuguese: embrião

- Spanish: embrión

------------

Thank you so much for being a member of our community!

Continued thread
Nonilex

The divide illustrates growing #Republican tensions over the political cost of the “#personhood” movement to endow an [potentially nonviable] #embryo w/ #HumanRights, which has animated the debate around #IVF. #Medical societies define PREGNANCY [not a person] as starting once an embryo has implanted in the wall of the uterus. But #conservative #legislators say they believe life begins when eggs are fertilized — before pregnancy — & are conflating #BirthControl w/ #abortion.

#law #BirthControl

Continued thread
William Lindsey :toad:

And:

"Donald Trump’s new 'let the states decide' position on abortion rights is a ploy. The real plan being cooked up by the Leonard Leo crew is to have the Supreme Court rule 'that a fetus qualifies as a "person" under the due process and equal protection clauses of the 14th Amendment,' which would make federal law the rightwing fairy tale that any abortion is equivalent to murder."

Since Leo owns the Supreme Court….

#abortion #FetalPersonhood #embryo #FederalistSociety #LeonardLeo
/2

William Lindsey :toad:

As Greg Olear notes, many of us may look at the blastocyst in the test tube and have trouble seeing the baby in the test tube — looking at you, Alabama Supremes. But that does not stop Leonard Leo of the Federalist Society and Robert P. George, a hard-right Catholic closely aligned with Leo, from their determination to impose on all of us by force of law the assertion that a blastocyst is a person.

#abortion #FetalPersonhood #embryo #FederalistSociety #LeonardLeo
/1

gregolear.substack.com/p/blast

PREVAIL by Greg Olear · Blastocysts Are People, TooBy Greg Olear
Benjamin Carr, Ph.D. 👨🏻‍💻🧬

Scientist who gene-edited babies is back in lab and ‘proud’ of past work despite jailing
In an interview with a Japanese newspaper, #HeJiankui said he had resumed research on human #embryo #geneediting, despite the controversy over the ethics of artificially rewriting genes, which some critics predicted would lead to demand for "designer babies."
theguardian.com/science/2024/a

Continued thread
Nonilex

The bill, signed into #law >3 wks after the #AlabamaSupremeCourt ruled that #FrozenEmbryos are people & individuals could be held #liable for destroying them, gives #criminal & #civil #immunity “for death or damage to an #embryo” related to #IVF. The unprecedented ruling alarmed #medical professionals & #ReproductiveRights advocates, who warned it would jeopardize IVF access. Several #Alabama providers halted IVF treatments w/in days of the decision.

#ReproductiveHealthCare#SCOTUS#Dobbs
Continued thread
Nonilex

…The measures that passed almost unanimously in both #Alabama chambers Thurs afternoon provide #legal #immunity “for death or damage to an #embryo to any individual or entity when providing or receiving goods or services related to in vitro fertilization.”

They provoked heated, highly emotional debate about #women’s #ReproductiveRights & how the #state has defined when life begins, most recently in a 2018 constitutional amendment cited in the court ruling.

#law#IVF
TrendingLive feeds
About